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KMID : 0358219920190020175
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Korean Journal of Fertility and Sterility
1992 Volume.19 No. 2 p.175 ~ p.180
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The Activity of Proliferating Cell Nuclear Antigen(PCNA) of Uterine Myoma after Treatment with Gonadotropin Releasing Hormone(GnRH) Analogue
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이병석
이보연/박기현/조동제/이국/송찬호/김호근
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Abstract
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The factors involved in the initial neoplastic transformation and subsquent growth of uterine fibroid are poorly understood. The reduction in uterine fibroid volume associated with the chronic administration of the mechanisms mediating the
decrease
in
fibroid volume in GnRH-a treated patients are poorly defined.
The purpose of this study was to determine the proliferating cell nuclear antigen (PCNA) in fibroid from-women pretreated with GnRH analogue (GnRH-a) compared with controls. Tissue was obtained from 16 premenopausal women with uterine fibroid who
received GnRH-a (D-Trp6-GnRH) intramusculary every 28 days for four injections. The mean proliferating index (PI) in patients with uterine fibroids was 2.25±0.9, and in controls was 8.82±1.8 (P<0.001). The proliferating index was not corrleated
with
the reduction of fibroid volume. In this clinical study, although hypostrogenism may be the main factor that reduce the volume of fibroid, other factors are also considered to be involved in that process. And the regrowth of uterine fibroid may
be
affected by increased production of PCNA after stopping GnRH-a.
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KEYWORD
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